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Sponsored| Name | Address | City |
|---|---|---|
| IU Health Addiction Treatment & Recovery Center – IU Health Methodist Hospital | 1730 N Capitol Ave Suite C3 | Indianapolis |
| CleanSlate Outpatient Addiction Medicine | 1725 N Meridian St | Indianapolis |
| AppleGate Recovery Indianapolis | 8140 Castleton Rd | Indianapolis |
| NuVitasGroup | 5218 S East St E3 | Indianapolis |
| Steven Segal Family Medicine | 1810 Broad Ripple Avenue Suite 1 | Indianapolis |
| Evolve Indy | 8770 Guion Rd Suite B | Indianapolis |
| Roudebush VA Medical Center | 1481 W. 10th. St | Indianapolis |
| Indianapolis Comprehensive Treatment Center | 2626 E 46th St Suite J | Indianapolis |
| Ascension St. Vincent Stress Center | 8401 Harcourt Boulevard | Indianapolis |
| Volunteers of America Brandon Hall | 611 N Capitol Ave | Indianapolis |
| Inspire Counseling & Support Center – Indianapolis | 10531 East 10th Street | Indianapolis |
| Ethan Crossing of Indianapolis | 4102 Shore Dr | Indianapolis |
| Journey Road Treatment Center – East | 1201 N Post Rd Suite 4 | Indianapolis |
| AppleGate Recovery Greenwood | 3623 E Southport Rd | Indianapolis |
| Sandra Eskenazi Mental Health Center | 832 North Meridian St. | Indianapolis |
| New Vista Outpatient Recovery Center | 65 Airport Parkway Suite 104 | Greenwood |
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Methadone and opioid use disorder treatment in Indianapolis
Indianapolis and the surrounding Marion County have one of Indiana’s deepest concentrations of opioid use disorder (OUD) treatment, with both opioid treatment programs (OTPs) that dispense methadone and office-based practices that prescribe buprenorphine and naltrexone. That means a person here usually has a real choice of medication and setting rather than a single option in a neighboring county. The medications for opioid use disorder (MOUD) covered on this page are methadone, buprenorphine (including Suboxone), and naltrexone (including the Vivitrol injection). The listings above show providers across the metro; you can call a clinic directly or use the helpline on this page to talk through a first step.
Your medication options and where each one is available
Three medications are approved to treat opioid use disorder, and they are not dispensed the same way. Methadone for OUD is provided only through a licensed opioid treatment program, not a regular pharmacy, so you receive it at a certified clinic. Buprenorphine, including Suboxone and the buprenorphine-naloxone combination, can be prescribed in a doctor’s office and filled at a pharmacy, or provided through a clinic; extended-release injectable buprenorphine such as Sublocade is also available. Naltrexone, including the monthly Vivitrol injection, can be prescribed by any licensed provider, but it is started only after a person has been off opioids for a set time.
Those routes map onto two settings. An opioid treatment program, or OTP, is the clinic model built around methadone and structured dosing. Office-based opioid treatment, or OBOT, is care from a physician, nurse practitioner, or physician assistant who prescribes buprenorphine or naltrexone you pick up at a pharmacy. Neither is better in the abstract; the right fit depends on the medication you and a clinician choose and how much structure helps you. If you are weighing the two, how methadone and Suboxone compare is a useful starting point, and the overview of what a methadone clinic involves explains day-to-day OTP care.
Starting treatment in Indianapolis and what intake looks like
Getting started usually begins with an intake assessment, where a clinician reviews your history, confirms a diagnosis, and helps you choose a medication. Some programs offer same-day or next-day intake; bring an ID and any insurance information you have, though lack of insurance does not bar you from being assessed. One practical caution matters if you have been using fentanyl: starting buprenorphine too soon after fentanyl can trigger sudden, severe withdrawal, called precipitated withdrawal, so a clinician times the first dose carefully and may suggest an alternative approach. This is a reason to be honest about recent use, not a reason to wait. You can read more about methadone treatment when fentanyl is involved, and the broader guide to opioid addiction treatment covers what to expect across settings.
Take-home doses, telehealth, and the current rules
Federal rules updated in 2024 reshaped what OTP care can look like. Under SAMHSA’s revision of 42 CFR Part 8, programs can now provide expanded take-home methadone, up to a 28-day supply for patients who are stable in treatment, on a graduated schedule, and the program decides eligibility based on your progress. The same update allowed treatment to start by telehealth and removed the old requirement that a person have a year of opioid addiction before being admitted. For buprenorphine, telehealth has gone further: as of mid-2026, it can be started through telehealth, including by phone in many cases, without a prior in-person visit. Those telehealth flexibilities run through the end of 2026 and are still being finalized, so confirm current options with a provider. Methadone for OUD remains dispensed through an OTP. If you are transferring care or returning after a gap, ask a program about guest dosing and long-term maintenance treatment; staying consistent with your dose protects the progress you have already made.
Paying for treatment
Cost is often the first worry, so start here. Indiana’s Medicaid expansion program, the Healthy Indiana Plan (HIP), covers adults ages 19 to 64 and is administered through managed care plans; as of January 1, 2026 those plans are Anthem, CareSource, and MHS, after MDwise left the program. Indiana eliminated prior authorization for FDA-approved opioid use disorder medications in 2020, and federal law now permanently requires state Medicaid programs to cover all three. Pregnant members are covered under HIP Maternity through pregnancy and for 12 months postpartum. Private insurance and Medicare also cover MOUD, and many OTPs offer self-pay or sliding-scale options. If you are unsure what you qualify for, a clinic’s intake staff or the helpline can help you sort it out before your first visit.
Overdose prevention and naloxone in Marion County
Marion County has seen real progress paired with continued risk. Fentanyl-related overdose deaths fell by nearly half, from 543 in 2023 to 296 in 2024, the lowest count since 2019, according to preliminary data from the Marion County Coroner’s Office and the Marion County Public Health Department. Fentanyl was still found in the large majority of overdose deaths, so the safety net matters. Naloxone, the medication that reverses an opioid overdose, is available without a personal prescription at Indiana pharmacies under a statewide standing order from the State Health Commissioner (Aaron’s Law), over the counter as Narcan, and free through community programs and the health department. Indiana’s Good Samaritan provisions offer limited protection from certain drug-possession charges for people who call 911 during an overdose. A return to use is a common and manageable part of recovery, not a failure; carrying naloxone and staying connected to care is the safest response. For more, see how to recognize and respond to an opioid overdose.
Pregnancy, reentry, and other specific situations
Some circumstances carry added stakes. For pregnancy, methadone and buprenorphine are the recommended standard of care; stopping opioids abruptly during pregnancy is not advised because it raises the risk of recurrence and harm to the pregnancy. Neonatal opioid withdrawal syndrome (NOWS) is an expected, manageable condition and is not a reason to avoid treatment. Indiana’s NextLevel Recovery initiative funded a perinatal treatment pilot that included Indianapolis, and HIP Maternity covers prenatal and postpartum care. A federal Plan of Safe Care is created when a newborn has been affected by substances, including prescribed MOUD; following recommended treatment is what clinicians advise. For people leaving the Marion County jail or returning from incarceration, the period right after release carries a high overdose risk, which makes continuing or restarting medication promptly a priority. Care is confidential, and methadone and pregnancy and the guidance for families go deeper on these situations.
Indianapolis treatment questions, answered
Is methadone available at a pharmacy in Indianapolis?
No. Methadone for opioid use disorder is dispensed only through a licensed opioid treatment program. Buprenorphine and naltrexone are the medications you can pick up at a pharmacy with a prescription.
Can I start Suboxone without going in person first?
Often yes. As of mid-2026, buprenorphine can be started by telehealth, including by phone in many cases, without a prior in-person visit. These rules run through the end of 2026 and are still being finalized, so confirm what is current with a provider.
Do I have to go to a clinic every day for methadone?
Not necessarily. Programs can provide take-home methadone, up to a 28-day supply for patients who are stable in treatment, under the 2024 federal rules. The program decides take-home eligibility based on your stability and progress.
Will Medicaid cover my treatment?
Indiana’s Healthy Indiana Plan covers all three opioid use disorder medications, and prior authorization for them was removed in 2020. Coverage details depend on your managed care plan; a clinic or the helpline can confirm before you start.
How do methadone and Suboxone differ?
Both reduce cravings and withdrawal and are effective. Methadone is dispensed through an OTP; buprenorphine can be prescribed in an office and filled at a pharmacy. The right choice is one you make with a clinician. See our questions and answers for more comparisons.
Last reviewed and disclosures
Last reviewed June 2026.
Sources
- U.S. Drug Enforcement Administration and HHS, Fourth Temporary Extension of COVID-19 Telemedicine Flexibilities, 2025-2026.
- SAMHSA, 42 CFR Part 8 final rule and MOUD overview, 2024.
- Marion County Coroner’s Office and Marion County Public Health Department, overdose data, 2024-2025.
- Indiana Family and Social Services Administration, Healthy Indiana Plan and managed care plan updates, 2025-2026.
- Indiana Department of Health, naloxone standing order and Aaron’s Law (IC 16-42-27).
- NextLevel Recovery Indiana, state opioid initiatives.
- CDC, treatment of opioid use disorder during pregnancy, 2026.
MethadoneCenters.com is a referrer service that provides information about addiction treatment practitioners and facilities. MethadoneCenters.com is not a medical provider or treatment facility and does not provide medical advice. The information provided is not a substitute for professional treatment advice.
Calls to any general helpline may be answered by a paid advertiser. We do not receive a commission or fee dependent on which treatment provider a caller chooses, and there is no obligation to enter treatment.