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Sioux Falls, the county seat of Minnehaha County, is the most populous in the U.S. state of South Dakota. The city is home to over a hundred thousand people, putting it up for consideration as a possible home to several people who are suffering from opioid dependency. Sioux Falls had a population estimated at 183,793 as of 2019. It has a total area of 206.2 km² in which some methadone clinics can be found. Residents of the city who want to treat opiate addiction medically may visit any Sioux Falls Methadone Clinic. Methadone clinics in South Dakota and other states specialize in the medical treatment of opiate addiction. The clinics dispense doses of methadone, a medication approved by the Food and Drug Administration for the correction of the negative effects of opioids. The drug has been added to the World Health Organization’s list of essential medications. Opioid withdrawal could be painful but methadone relieves the pain. The medication should not be taken without a prescription from a medication-assisted treatment practitioner because its misuse is dangerous. The opioid treatment program is optional. The patient must be told about the health risk factors after informing the healthcare professional about their health history. An opioid treatment program could run for several years.