There are over one and a half thousand cities bigger than South Portland in the U.S, but its 25,606 population as of 2018, and an area of 36.29 km² makes it rank as the fourth-largest city in the U.S. state of Maine. People who need medical assistance to overcome opioid dependency in this city may find some help in any methadone clinic South Portland Maine. Methadone is one of the approved drugs by the Food and Drug Administration for the treatment of opioid dependency. Opioid use disorder has become a serious problem for many people. Opioid relieves pains and gives euphoria. People who take it once are at the risk of taking it time and again until it becomes an addiction. Methadone is a safe drug to correct this. Opioid addiction can cause lots of psychological issues. Methadone blocks some of these effects. As effective as it is, Methadone is regulated to avoid diversion into the illicit market. It is to be taken under the supervision of a health provider and that is done in combination with counseling and behavioral therapies. All methadone clinics in Maine are required to register with the Drug Enforcement Administration. Before treatment with methadone, the patient must be given adequate information which includes possible side effects. Methadone is safe, however.