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Portland, the county seat of Cumberland County, is the largest city in the state of Maine. It has a population estimated at 66,215 as of 2019. With an area of 179.8 km², Portland is not one of the smallest cities in the U.S. As the largest city in Maine, there is a high probability that there are people suffering from opioid addiction. Such people may visit any methadone clinic Portland for assistance. Methadone clinics are established for the dispensing of medications used in the treatment of opioid use disorder. Methadone is one of the three approved drugs by the Food and Drug Administration for the treatment of substance use disorder. Before dispensing methadone, all methadone clinics in Maine must register with the Drug Enforcement Administration. Methadone blunts the effects of opioids. It is safe if taken as prescribed by the medication-assisted treatment practitioner. Doses of methadone are not to be shared because they are tailored for individuals according to their situation. Methadone maintenance is rarely short-term, lasting for about twelve months. Usually, maintenance takes time, and it could go on indefinitely. The duration of maintenance is not as important as the result. Maintenance, short-term or long-term, is safe. Clinics combine doses with counseling and behavioral therapies for effect.