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Calais, a city in Washington County, is one of the least-populous cities in the U.S. state of Maine. Over the years, the city has recorded a consistent decrease in population. With a population estimated at 2,989 as of 2018 and an area of 103.9 km², there is, without doubts, enough space for more people. The population does not rule out the possibility of having inhabitants who are suffering from opioid use disorder. They may visit any methadone clinic in Calais Maine to get medication-assisted treatment. Methadone is a drug approved by the Food and Drug Administration for the treatment of opioid use disorder. It is available in powder, diskettes, and liquid forms. Although methadone has been found so effective that it made the World Health Organization’s list of essential medications, it should not be taken without the supervision of a medication-assisted treatment professional because misuse of methadone could be hazardous. All methadone clinics in Maine are required to be accredited by the Substance Abuse and Mental Health Services Administration. Methadone maintenance is regulated to avoid diverting doses to the illicit market. What makes a complete medication-assisted treatment is the combination of doses of methadone with counseling and behavioral therapies. Methadone reduces craving. It is safe and effective.